Understanding how genetic differences affect sensitivity to harmful environmental chemicals
Official title: Mechanisms Controlling Sensitivity and Resistance to Dioxin-like Compounds: Role of AIP
Funded at Woods Hole Oceanographic Institution · NIH-10538943 · Data updated 2026-11-12
This study is looking at how a protein called AIP affects how people react to harmful chemicals in the environment, like dioxins, to help understand why some folks are more sensitive to these toxins than others, which could give patients helpful information about their own risks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Woods Hole Oceanographic Institution NIH-funded |
| Lab location | 1 site (Woods Hole, United States) |
| Project start | September 7, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $1,839,380 |
| NIH project number | 1R01ES033888-01A1 |
| Project ID | NIH-10538943 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of sensitivity to environmental toxins or related health issues.
✕Less likely to help
Patients who do not have any known genetic predispositions to environmental toxin sensitivity may not benefit from this research.
What this research studies
This research investigates the role of a protein called Aryl Hydrocarbon Receptor-Interacting Protein (AIP) in how individuals respond to toxic environmental compounds like dioxins and polychlorinated biphenyls. By studying genetic variations in AIP, the research aims to uncover why some people are more susceptible to the harmful effects of these chemicals than others. The approach includes examining both human genetic data and laboratory studies in animal models to understand the mechanisms involved. Patients may gain insights into their own susceptibility to environmental toxins based on their genetic makeup.
Why it matters
Potential benefit: If successful, this research could lead to personalized strategies for protecting individuals from the harmful effects of environmental toxins.
How similar studies have gone: Previous research has shown that understanding genetic variations can significantly impact how individuals respond to environmental toxins, suggesting this approach has potential for success.
Where this research is happening
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Woods Hole Oceanographic Institution
Woods Hole, United States Active
Researchers
- Principal investigator: Hahn, Mark E — Woods Hole Oceanographic Institution
- Study coordinator: Hahn, Mark E
Related research
Other NIH-funded projects on the same topics.
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How the AIP protein changes sensitivity to dioxin-like chemicals
This project looks at whether different versions of the AIP protein make people and animals more or less affected by dioxins and similar environmental chemicals.
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Exploring how the aryl hydrocarbon receptor interacts with various chemicals
This study is looking at a protein called AHR that helps our bodies deal with harmful substances from the environment, and it's for anyone interested in how this protein affects our health and development.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.