Exploring how the aryl hydrocarbon receptor interacts with various chemicals
Official title: Understanding the origins and mechanisms of aryl hydrocarbon receptor promiscuity
Funded at Woods Hole Oceanographic Institution · NIH-11001840 · Data updated 2026-11-12
This study is looking at a protein called AHR that helps our bodies deal with harmful substances from the environment, and it's for anyone interested in how this protein affects our health and development.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Woods Hole Oceanographic Institution NIH-funded |
| Lab location | 1 site (Woods Hole, United States) |
| Project start | March 9, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $494,631 |
| NIH project number | 5R01ES035261-03 |
| Project ID | NIH-11001840 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals exposed to environmental toxins or those with conditions influenced by the immune system and metabolic processes.
✕Less likely to help
Patients who are not exposed to environmental toxins or do not have related health conditions may not benefit from this research.
What this research studies
This research investigates the aryl hydrocarbon receptor (AHR), a protein that plays a crucial role in how our bodies respond to environmental toxins and other substances. By examining how AHR interacts with a wide range of chemicals, including pollutants and dietary compounds, the research aims to uncover the mechanisms behind its diverse functions in health and disease. The approach involves innovative molecular studies to understand the structure and function of AHR, which could lead to insights into its role in various physiological processes such as immunity and development.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of how environmental exposures affect health, potentially leading to better prevention and treatment strategies for related diseases.
How similar studies have gone: Other research has shown success in understanding the roles of similar receptors in health and disease, indicating that this approach has potential for meaningful insights.
Where this research is happening
-
Woods Hole Oceanographic Institution
Woods Hole, United States Active
Researchers
- Principal investigator: Hahn, Mark E — Woods Hole Oceanographic Institution
- Study coordinator: Hahn, Mark E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.