NIH-funded research P01 program project

Environmental drivers of toxic algal blooms and shellfish toxin risk

Official title: Project 2: Environmental forcing of harmful algal blooms and toxicity exposure

Funded at Woods Hole Oceanographic Institution · NIH-11360099 · Data updated 2026-11-12

Researchers are building models to predict when toxic algae will bloom and how people who eat shellfish or live near the coast might be exposed to toxins.

Quick facts

Grant typeP01 program project
Study typeNIH-funded research
Funding institutionWoods Hole Oceanographic Institution
NIH-funded
Lab location1 site (Woods Hole, United States)
Project startSeptember 30, 2018
Project endFebruary 28, 2029
Funding year2026
Award (this year)$136,377
NIH project number5P01ES028938-08
Project IDNIH-11360099 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates include people who harvest or frequently eat shellfish, live in affected coastal regions, or participate in community shellfish monitoring programs.

Less likely to help

People with health concerns unrelated to seafood toxin exposure or those living far from coastal shellfish areas may not directly benefit.

What this research studies

Researchers will combine ocean observations, lab studies of toxin-producing algae (Alexandrium catenella and Pseudo-nitzschia), and computer models to understand bloom timing and toxicity. They will update an Alexandrium model, develop a Pseudo-nitzschia model, and run hindcast simulations for the Gulf of Maine, comparing results to shellfish toxin measurements and other observations. A submodel will estimate human exposure to saxitoxin and domoic acid and models will be refined iteratively until they match real-world data before being used to forecast future events. The team will also apply and test their approach in Nauset Marsh and coastal Arctic settings to see how regional conditions change risks.

Why it matters

Potential benefit: If successful, this work could give communities earlier warnings about toxic shellfish and help prevent poisonings.

How similar studies have gone: Prior monitoring and forecasting efforts have helped reduce some toxin exposures, and this project builds on that work with newer, region-specific models and expanded testing.

Where this research is happening

  • Woods Hole Oceanographic Institution
    Woods Hole, United States
    Active

Researchers

  • Principal investigator: Ralston, David K — Woods Hole Oceanographic Institution
  • Study coordinator: Ralston, David K

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.