Understanding how genetic differences affect blood cell production and response to infections.
Official title: Genetic Variation and Inflammation-Dependent Hematopoietic Regulatory Networks
Funded at University of Wisconsin-Madison · NIH-11004632 · Data updated 2026-11-12
This study is looking at how certain genes affect the way your body makes blood cells, especially when dealing with infections or inflammation, to help us understand blood disorders like acute myeloid leukemia (AML), so that patients can learn how their genetics might influence their blood health and treatment options.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | January 1, 2024 |
| Project end | November 30, 2025 |
| Funding year | 2025 |
| Award (this year) | $188,544 |
| NIH project number | 5R21AI178647-02 |
| Project ID | NIH-11004632 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with genetic variations linked to hematopoietic disorders, such as acute myeloid leukemia.
✕Less likely to help
Patients without genetic predispositions to hematopoietic disorders or those not affected by blood cell production issues may not benefit from this research.
What this research studies
This research investigates how genetic variations influence the regulatory networks that control blood cell production, particularly in response to infections and inflammation. By studying specific genetic mutations in mice that mimic human conditions, the research aims to uncover the mechanisms that lead to blood disorders like acute myeloid leukemia (AML). The approach includes analyzing how these genetic factors affect the behavior of hematopoietic stem and progenitor cells (HSPCs) during stress conditions, such as chemotherapy and chronic inflammation. Patients may benefit from insights gained into how their genetic makeup could impact their blood health and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with blood disorders, particularly those with genetic predispositions.
How similar studies have gone: Previous research has shown success in understanding genetic influences on blood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Bresnick, Emery H — University of Wisconsin-Madison
- Study coordinator: Bresnick, Emery H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.