Understanding how genetic changes affect brain cell development in Down Syndrome
Epigenetic Determinants in Oligodendrocyte Maturation in Down Syndrome
This study is looking at how genetic changes in people with Down Syndrome affect the growth of important brain cells that help with communication between nerve cells, and it aims to find out how these changes might relate to the learning challenges some individuals with Down Syndrome experience.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10527889 on NIH RePORTER |
What this research studies
This research investigates the impact of genetic changes associated with Down Syndrome on the maturation of oligodendrocytes, which are crucial for myelin production in the brain. By utilizing human patient-derived induced pluripotent stem cells, the study aims to explore how epigenetic alterations influence the development and function of these brain cells. The researchers will employ a novel 3D cellular model to better understand the cellular mechanisms at play. This approach could provide insights into the cognitive challenges faced by individuals with Down Syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with Down Syndrome who may benefit from advancements in understanding their condition.
Not a fit: Patients without Down Syndrome or those who are not adults may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies aimed at improving cognitive function in individuals with Down Syndrome.
How similar studies have performed: Previous research has shown promising results in understanding myelination and cognitive function in Down Syndrome, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Zeldich, Ella — Boston University Medical Campus
- Study coordinator: Zeldich, Ella
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.