Understanding how G proteins regulate PLCbeta enzymes
Official title: Mechanisms Underlying Regulation of PLCbeta by heterotrimeric G proteins
Funded at Purdue University · NIH-10988727 · Data updated 2026-11-12
This study is looking at how certain enzymes help control calcium levels in our cells, which is important for keeping our cells healthy, and it could help find new treatments for serious health problems like heart disease and cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | August 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $347,615 |
| NIH project number | 1R01GM152701-01A1 |
| Project ID | NIH-10988727 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with heart disease, certain types of cancer, or conditions related to calcium signaling abnormalities.
✕Less likely to help
Patients with conditions unrelated to PLCb activity or those not experiencing calcium signaling issues may not benefit from this research.
What this research studies
This research investigates the role of phospholipase C beta (PLCb) enzymes in regulating calcium levels within cells, which is crucial for various cellular processes like growth and survival. It focuses on how these enzymes are activated by G proteins and how their dysfunction can lead to serious health issues such as heart disease and cancer. By using advanced techniques like cryo-electron microscopy, the study aims to uncover the detailed mechanisms of PLCb activation and its isoform-specific responses. This knowledge could lead to new therapeutic strategies for conditions linked to PLCb dysregulation.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for heart disease, cancer, and other conditions related to PLCb dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding G protein interactions with other enzymes, suggesting potential for success in this area as well.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Lyon, Angeline Marie — Purdue University
- Study coordinator: Lyon, Angeline Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.