Understanding how FSH receptor teamwork changes with age to affect ovarian aging
Official title: Understanding The Role Of FSHR Oligomerization And Trafficking In Transducing Age-dependent Changes In FSH Glycoforms
Funded at King's College London · NIH-11377552 · Data updated 2026-11-12
A study from King's College London will explore how different forms of the hormone FSH interact with its receptor as women age, to see if this affects ovarian aging and related health risks.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | King's College London NIH-funded |
| Lab location | 1 site (London, United Kingdom) |
| Project start | August 19, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $362,371 |
| NIH project number | 5R01HD113570-03 |
| Project ID | NIH-11377552 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are women experiencing early-stage ovarian aging or peri-menopause who could contribute tissue or biological samples and participate in related future studies.
✕Less likely to help
Individuals without aging-related ovarian changes or related health concerns may not directly benefit from these findings.
What this research studies
This project will look at how aging changes the way FSH and its receptor work together in the ovaries, focusing on the different glycoforms of FSH and how they signal through FSHR. Researchers will use molecular approaches such as ATAC sequencing to study chromatin accessibility and how aging alters gene regulation related to FSH signaling. The goal is to uncover mechanisms that could someday extend ovarian lifespan and reduce age-related health problems like osteoporosis. The study involves analysis of human biology in the context of aging and may translate to new strategies to maintain women's reproductive health.
Why it matters
Potential benefit: If successful, findings could guide new approaches to delay ovarian aging and lessen related health risks for women.
How similar studies have gone: Previous work shows that different FSH glycoforms have distinct signaling, supporting the plausibility of age-related differences in FSH signaling.
Where this research is happening
-
King's College London
London, United Kingdom Active
Researchers
- Principal investigator: Jonas, Kim Carol — King's College London
- Study coordinator: Jonas, Kim Carol
Related research
Other NIH-funded projects on the same topics.
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How Hormones Change with Age to Affect Ovarian Function
This project explores how different forms of a hormone called FSH affect the ovaries as women get older, aiming to find new ways to support ovarian health.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.