NIH-funded research NIH-funded research

Understanding and preventing early-onset colorectal cancer

Official title: PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors

Funded at King's College London · NIH-11043055 · Data updated 2026-11-12

This study is looking at what causes colorectal cancer in people under 50, focusing on how biology, environment, and lifestyle choices work together, so we can find better ways to prevent this disease.

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Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionKing's College London
NIH-funded
Lab location1 site (London, United Kingdom)
Project startMay 1, 2024
Project endApril 30, 2026
Funding year2024
Award (this year)$333,293
NIH project number1OT2CA297289-01
Project IDNIH-11043055 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are individuals under 50 years old who may be at risk for colorectal cancer due to genetic, environmental, or lifestyle factors.

Less likely to help

Patients over the age of 50 or those with established colorectal cancer may not benefit from this research.

What this research studies

This research investigates the complex factors that lead to colorectal cancer in individuals under 50 years old. By examining biological, environmental, and lifestyle influences, the team aims to identify key risk factors and mechanisms that contribute to the disease. The study utilizes advanced animal models and data analysis to explore how these factors interact over a person's lifetime. Ultimately, the goal is to develop effective prevention strategies that can be implemented to reduce the incidence of early-onset colorectal cancer.

Why it matters

Potential benefit: If successful, this research could lead to new prevention strategies that significantly reduce the risk of colorectal cancer in younger individuals.

How similar studies have gone: Previous research has shown promise in understanding risk factors for colorectal cancer, but this approach is innovative in its focus on early-onset cases.

Where this research is happening

  • King's College London
    London, United Kingdom
    Active

Researchers

  • Principal investigator: Spector, Tim — King's College London
  • Study coordinator: Spector, Tim

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.