Understanding and preventing early-onset colorectal cancer
Official title: PROSPECT: Pathways, Risk factors, and mOleculeS to Prevent Early-onset Colorectal Tumors
Funded at King's College London · NIH-11043055 · Data updated 2026-11-12
This study is looking at what causes colorectal cancer in people under 50, focusing on how biology, environment, and lifestyle choices work together, so we can find better ways to prevent this disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | King's College London NIH-funded |
| Lab location | 1 site (London, United Kingdom) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $333,293 |
| NIH project number | 1OT2CA297289-01 |
| Project ID | NIH-11043055 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 50 years old who may be at risk for colorectal cancer due to genetic, environmental, or lifestyle factors.
✕Less likely to help
Patients over the age of 50 or those with established colorectal cancer may not benefit from this research.
What this research studies
This research investigates the complex factors that lead to colorectal cancer in individuals under 50 years old. By examining biological, environmental, and lifestyle influences, the team aims to identify key risk factors and mechanisms that contribute to the disease. The study utilizes advanced animal models and data analysis to explore how these factors interact over a person's lifetime. Ultimately, the goal is to develop effective prevention strategies that can be implemented to reduce the incidence of early-onset colorectal cancer.
Why it matters
Potential benefit: If successful, this research could lead to new prevention strategies that significantly reduce the risk of colorectal cancer in younger individuals.
How similar studies have gone: Previous research has shown promise in understanding risk factors for colorectal cancer, but this approach is innovative in its focus on early-onset cases.
Where this research is happening
-
King's College London
London, United Kingdom Active
Researchers
- Principal investigator: Spector, Tim — King's College London
- Study coordinator: Spector, Tim
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.