How Hormones Change with Age to Affect Ovarian Function
Official title: Understanding The Role Of FSHR Oligomerization And Trafficking In Transducing Age-dependent Changes In FSH Glycoforms
Funded at King's College London · NIH-11172403 · Data updated 2026-11-12
This project explores how different forms of a hormone called FSH affect the ovaries as women get older, aiming to find new ways to support ovarian health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | King's College London NIH-funded |
| Lab location | 1 site (London, United Kingdom) |
| Project start | August 19, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $352,847 |
| NIH project number | 5R01HD113570-02 |
| Project ID | NIH-11172403 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is relevant to women experiencing or approaching ovarian aging and its associated health changes.
✕Less likely to help
Patients not experiencing ovarian aging or related conditions may not directly benefit from this specific research focus.
What this research studies
As women age, their ovaries naturally change, which can lead to health issues like osteoporosis. Currently, there are no treatments to prevent or delay this process, highlighting a need for new approaches to extend ovarian lifespan. This project looks at follicle stimulating hormone (FSH), which comes in different forms that have distinct effects on the ovaries. We know that the less potent form of FSH increases around menopause, coinciding with ovaries becoming less responsive to FSH. This research aims to uncover how these different FSH forms influence ovarian function during aging.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for delaying or preventing ovarian aging, potentially improving women's quality of life and reducing health burdens.
How similar studies have gone: Age-related changes in human pituitary extracts have been reported, showing shifts in FSH forms, but the specific mechanisms explored here are largely unknown.
Where this research is happening
-
King's College London
London, United Kingdom Active
Researchers
- Principal investigator: Jonas, Kim Carol — King's College London
- Study coordinator: Jonas, Kim Carol
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.