Understanding how fibroblasts affect bladder function
Role of fibroblasts in bladder mucosal function
This study is looking at special cells in the bladder that help keep it flexible and working properly, which could lead to new ways to help people with bladder problems feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11044517 on NIH RePORTER |
What this research studies
This research investigates the role of fibroblasts in the bladder's connective tissue and how they contribute to bladder function. It focuses on a specific type of fibroblast known as suburothelial fibroblasts, which are believed to help maintain the bladder's elasticity and contractility. By using advanced imaging techniques and genetic analysis, the research aims to uncover how these cells interact with the bladder's structure and nerve signaling. The findings could lead to better understanding and treatment options for patients with bladder dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients suffering from bladder dysfunctions such as neurogenic bladder, outlet obstruction, or radiation cystitis.
Not a fit: Patients with normal bladder function or those not experiencing any bladder-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bladder conditions that result from stiff or fibrotic bladders.
How similar studies have performed: Other research has shown promising results in understanding the role of fibroblasts in various tissues, suggesting that this approach could yield valuable insights.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Carattino, Marcelo Daniel — University of Pittsburgh at Pittsburgh
- Study coordinator: Carattino, Marcelo Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.