Understanding how exercise can rejuvenate aging muscles
Official title: Mediators of Muscle Rejuvenation with Aging
Funded at University of Arkansas at Fayetteville · NIH-11137367 · Data updated 2026-11-12
This study is looking at how getting older affects our muscles and whether exercise can help improve muscle health by focusing on a special protein called MYC, and it's designed for older adults who want to understand how to keep their muscles strong as they age.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arkansas at Fayetteville NIH-funded |
| Lab location | 1 site (Fayetteville, United States) |
| Project start | June 1, 2025 |
| Project end | July 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $141,890 |
| NIH project number | 1K02AG088465-01A1 |
| Project ID | NIH-11137367 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing age-related muscle decline.
✕Less likely to help
Patients who are younger than 21 or do not have age-related muscle decline may not benefit from this research.
What this research studies
This research investigates how aging affects muscle function and how exercise can potentially reverse these effects. It focuses on a specific protein, MYC, which is influenced by exercise and plays a crucial role in muscle health. Using a mouse model, the study will analyze how MYC induction and exercise impact muscle cells at a molecular level, including their energy use and genetic changes. The goal is to uncover mechanisms that could lead to improved muscle function in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing muscle health and function in older adults, potentially improving their quality of life.
How similar studies have gone: Previous research has shown that exercise can positively impact muscle function in aging populations, suggesting that this approach may yield beneficial results.
Where this research is happening
-
University of Arkansas at Fayetteville
Fayetteville, United States Active
Researchers
- Principal investigator: Murach, Kevin — University of Arkansas at Fayetteville
- Study coordinator: Murach, Kevin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.