Understanding how exercise can rejuvenate aging muscles
Official title: Mediators of Muscle Rejuvenation with Aging
Funded at University of Arkansas at Fayetteville · NIH-11083064 · Data updated 2026-11-12
This study is looking at how getting older affects our muscles and whether exercise can help keep them strong, focusing on a special protein called MYC that plays an important role in muscle health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arkansas at Fayetteville NIH-funded |
| Lab location | 1 site (Fayetteville, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $648,544 |
| NIH project number | 5R01AG080047-03 |
| Project ID | NIH-11083064 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who are experiencing age-related muscle decline.
✕Less likely to help
Patients who are not experiencing age-related muscle decline or who are under 21 years old may not benefit from this research.
What this research studies
This research investigates how aging affects muscle function and how exercise can potentially reverse these effects. It focuses on a specific protein, MYC, which is influenced by exercise and plays a crucial role in muscle health. Using a mouse model, the study will analyze muscle cells' responses to exercise and MYC induction over time, aiming to uncover the molecular mechanisms behind muscle aging. The findings could provide insights into how to maintain muscle health as we age.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving muscle function and overall health in older adults.
How similar studies have gone: Previous research has shown that exercise can positively impact muscle health, but this specific approach focusing on MYC is novel.
Where this research is happening
-
University of Arkansas at Fayetteville
Fayetteville, United States Active
Researchers
- Principal investigator: Murach, Kevin — University of Arkansas at Fayetteville
- Study coordinator: Murach, Kevin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.