Understanding how enterococci bacteria resist antibiotics
Official title: Role and regulation of intracellular signaling in enterococcal antimicrobial resistance
Funded at Medical College of Wisconsin · NIH-11015066 · Data updated 2026-11-12
This study is looking into how certain bacteria that can cause serious infections in hospitals become resistant to antibiotics, specifically focusing on how their internal signals help them resist treatment, with the hope of finding new ways to help patients get better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | February 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $630,730 |
| NIH project number | 5R01AI175261-02 |
| Project ID | NIH-11015066 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients who have infections caused by enterococci, particularly those that are resistant to standard antibiotic treatments.
✕Less likely to help
Patients with infections caused by bacteria other than enterococci may not receive benefit from this research.
What this research studies
This research investigates the mechanisms behind antibiotic resistance in enterococci, which are bacteria that can cause serious hospital-acquired infections. The study focuses on the role of intracellular signaling and how it regulates the bacteria's resistance to cephalosporins, a common class of antibiotics. By exploring the genetic and biochemical factors that contribute to this resistance, the research aims to identify new therapeutic targets. Patients may benefit from improved treatment options if new strategies to combat these resistant infections are developed.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for infections caused by antibiotic-resistant enterococci.
How similar studies have gone: Other research has shown promise in understanding antibiotic resistance mechanisms, but this specific approach focusing on intracellular signaling in enterococci is relatively novel.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Kristich, Christopher J — Medical College of Wisconsin
- Study coordinator: Kristich, Christopher J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.