Understanding how early brain development affects cognitive speed in mice with genetic disorders
Official title: Identifying a critical developmental period for cognitive speed in a mouse model for neurodevelopmental disorders
Funded at University of Texas Hlth Science Center · NIH-11067729 · Data updated 2026-11-12
This study is looking at how a gene called TBX1 affects brain development and thinking skills in mice, which could help us understand how similar issues might impact brain development and learning in people.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $42,312 |
| NIH project number | 5F30MH134482-02 |
| Project ID | NIH-11067729 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals under 21 years old with conditions related to the 22q11.2 deletion syndrome or similar neurodevelopmental disorders.
✕Less likely to help
Patients who do not have neurodevelopmental disorders or are over 21 years old may not benefit from this research.
What this research studies
This research investigates the role of a specific gene, TBX1, in the early development of the brain and its impact on cognitive abilities in mice. By studying mice with a genetic deletion associated with neurodevelopmental disorders, the researchers aim to identify critical periods during which brain development influences cognitive speed. The approach involves manipulating gene expression during specific developmental stages and assessing the resulting cognitive performance in tasks related to attention and memory. This could provide insights into how similar processes might affect human cognitive development.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential interventions for cognitive impairments associated with neurodevelopmental disorders in humans.
How similar studies have gone: Previous research has shown that understanding genetic influences on brain development can lead to significant advancements in treating cognitive impairments, suggesting this approach has potential for success.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Wells, Anne Marie — University of Texas Hlth Science Center
- Study coordinator: Wells, Anne Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.