Understanding how DNA replication machinery evolves and adapts.
Official title: Mechanism and Evolutionary Design of DNA Polymerase Clamp Loaders.
Funded at Vanderbilt University · NIH-11051900 · Data updated 2026-11-12
This study is looking at how certain proteins help our cells copy DNA quickly and accurately, which is important for keeping our genes healthy, and the findings could lead to new treatments for patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | April 1, 2023 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $322,500 |
| NIH project number | 5R01GM144512-03 |
| Project ID | NIH-11051900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with genetic disorders related to DNA replication errors.
✕Less likely to help
Patients with conditions unrelated to DNA replication or those not affected by genetic disorders may not receive direct benefits from this research.
What this research studies
This research investigates the evolutionary mechanisms behind complex molecular machines that are crucial for DNA replication. By utilizing high-throughput mutagenesis and functional studies, the team will explore how proteins known as sliding clamps and their associated clamp loaders work together to facilitate rapid DNA replication. The study focuses on the intricate interactions and adaptations of these proteins, which are essential for maintaining genetic integrity and adaptability in organisms. Patients may benefit from insights gained into the fundamental processes of DNA replication, which could inform future therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to advancements in understanding genetic replication processes, potentially impacting treatments for genetic disorders.
How similar studies have gone: Other research has shown success in understanding molecular machines and their roles in cellular processes, suggesting that this approach has a solid foundation.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Kuriyan, John — Vanderbilt University
- Study coordinator: Kuriyan, John
Related research
Other NIH-funded projects on the same topics.
-
Understanding how peer norms around alcohol and HIV prevention affect adolescents and young adults in rural Uganda
This project studies how what young people think their peers do or approve of influences drinking and HIV prevention behaviors in rural Uganda, with the goal of improving health outcomes.
-
Cancer Pain Management for Asian American Breast Cancer Survivors with Depressive Symptoms
A technology-based program helps Asian American breast cancer survivors with depressive symptoms manage chronic pain more effectively from home using a web app and mobile tools.
-
Targeted gene silencing in the brain using siRNA helpers
This grant tests a new way to turn off specific brain genes in particular CNS cell types using siRNA conjugates to help understand brain biology and disease.
-
RSELVES Study: How older couples influence daily life and function with Alzheimer’s risk
A study to understand how daily routines and support between older adults and their partners relate to the development of Alzheimer’s-related functional decline.
-
Molecular mechanisms of coat assembly and regulation in membrane trafficking
A research project seeks to understand how cellular coats organize and regulate the delivery of membrane-bound cargo, with a focus on proteins related to neurological diseases.
-
Synaptic nanostructure in neurodevelopmental disorders
This project aims to map the tiny architecture of brain synapses in native cells to understand how connections form and change in neurodevelopmental disorders.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.