Molecular mechanisms of coat assembly and regulation in membrane trafficking
Official title: Molecular mechanisms of coat assembly and regulation in membrane trafficking pathways
Funded at Vanderbilt University · NIH-11522666 · Data updated 2026-11-12
A research project seeks to understand how cellular coats organize and regulate the delivery of membrane-bound cargo, with a focus on proteins related to neurological diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | July 1, 2026 |
| Project end | March 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $77,898 |
| NIH project number | 3R35GM119525-10S1 |
| Project ID | NIH-11522666 on NIH RePORTER |
Who could benefit from this research
✓Could help
No specific patient enrollment is required for this mechanistic study; results may ultimately benefit patients with neurodegenerative diseases through improved understanding of cellular processes.
✕Less likely to help
The study itself does not enroll patients and may not provide direct benefits to participants.
What this research studies
This NIH grant aims to uncover how coat protein complexes form and control vesicle traffic inside cells, which is important for brain health. Researchers will study the retromer and COPI/AP coat families using biochemical and structural methods to map interactions and functions. The work could reveal how defects in trafficking contribute to neurodegenerative conditions like Alzheimer’s disease and related dementias. Findings may illuminate targets for therapies that protect neuronal communication and health.
Why it matters
Potential benefit: Insights from this work could lead to new approaches for preventing or treating neurological disorders by improving cellular transport.
How similar studies have gone: Past work on coat complexes like clathrin has advanced understanding of vesicle formation, supporting the potential for meaningful discoveries here.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Jackson, Lauren Parker — Vanderbilt University
- Study coordinator: Jackson, Lauren Parker
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.