Understanding how DNA damage affects aging
Official title: Core E: Models of Genome Instability and Aging
Funded at University of Minnesota · NIH-11117551 · Data updated 2026-11-12
This study is looking at how damage to our DNA affects aging and could lead to health problems as we get older, and it aims to find ways to help prevent or treat these issues for people like you.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | June 17, 2025 |
| Project end | May 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $254,100 |
| NIH project number | 1P30AG092751-01 |
| Project ID | NIH-11117551 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing accelerated aging or age-related chronic conditions.
✕Less likely to help
Patients who are not experiencing age-related issues or DNA repair defects may not benefit from this research.
What this research studies
This research investigates the role of DNA damage in the aging process, focusing on how both external and internal factors contribute to genome instability. By analyzing human samples and mouse models with DNA repair defects, the research aims to uncover the molecular and cellular impacts of DNA damage over time. The study will explore how these changes may lead to age-related diseases and chronic conditions, providing insights into potential interventions. Patients may benefit from findings that could lead to new treatments or preventative strategies for age-related health issues.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related diseases by targeting DNA damage.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between DNA damage and aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Niedernhofer, Laura Jane — University of Minnesota
- Study coordinator: Niedernhofer, Laura Jane
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.