Understanding how diet affects brain behavior in fish.
Official title: Gene Coexpression Network Regulating Repetitive Behavior under Nutritional Change.
Funded at University of Hawaii at Manoa · NIH-11096925 · Data updated 2026-11-12
This study is looking at how different diets can affect the behavior and brain activity of fish, especially focusing on cavefish and surface fish, to see if changes in nutrition can help us understand repetitive behaviors better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Hawaii at Manoa NIH-funded |
| Lab location | 1 site (Honolulu, United States) |
| Project start | September 25, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $182,860 |
| NIH project number | 3R01GM148960-02S1 |
| Project ID | NIH-11096925 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals interested in the effects of nutrition on behavior, particularly those with conditions related to repetitive behaviors.
✕Less likely to help
Patients who do not have an interest in or are not affected by behavioral conditions related to dietary changes may not benefit from this research.
What this research studies
This research investigates how changes in nutrition influence repetitive behaviors in fish by examining their brain activity. Using advanced 3-D imaging technology, the study aims to analyze the neural networks of cavefish and surface fish, particularly focusing on the dopaminergic and GABAergic systems. The researchers will utilize a new automated fluorescent microscope that significantly speeds up the imaging process, allowing for more efficient data collection. By scanning multiple brains quickly, the study seeks to uncover how dietary changes, such as a ketogenic diet, may alter brain function and behavior.
Why it matters
Potential benefit: If successful, this research could lead to new insights into how diet influences brain function and behavior, potentially informing dietary recommendations for various conditions.
How similar studies have gone: Previous research has shown promising results in understanding the relationship between diet and brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Hawaii at Manoa
Honolulu, United States Active
Researchers
- Principal investigator: Yoshizawa, Masato — University of Hawaii at Manoa
- Study coordinator: Yoshizawa, Masato
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.