Understanding how dengue virus makes its RNA to help create antivirals and vaccines
Official title: MECHANISM OF RNA SYNTHESIS BY DENGUE VIRUS NS5
Funded at Trustees of Indiana University · NIH-11362342 · Data updated 2026-11-12
Researchers study how the dengue virus copies its RNA inside cells to find targets for new antiviral medicines and vaccines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | March 10, 2011 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $458,340 |
| NIH project number | 5R01AI087856-14 |
| Project ID | NIH-11362342 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not directly applicable to patients in this basic research grant; results may later benefit those at risk of dengue and related viruses.
✕Less likely to help
No immediate patient participation or direct benefit in this non-human, basic science study.
What this research studies
This project looks at the flaviviruses like dengue, West Nile, and Zika to understand how the virus replication machinery works inside human cells. By examining the structural and biochemical steps of RNA synthesis, scientists aim to identify weaknesses that new drugs or vaccines could exploit. The work involves detailed laboratory analyses of viral proteins and RNA interactions to map how replication is initiated and controlled. The ultimate goal is to translate these insights into therapeutics and preventive strategies that could protect people from these infections.
Why it matters
Potential benefit: Could lead to new antiviral drugs or vaccines that prevent or treat dengue and related diseases.
How similar studies have gone: Previous research on flavivirus replication has informed antiviral development, suggesting this approach is promising but still requires further validation.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Choi, Kyung H — Trustees of Indiana University
- Study coordinator: Choi, Kyung H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.