Understanding How Dengue Virus Copies Itself
Official title: MECHANISM OF RNA SYNTHESIS BY DENGUE VIRUS NS5
Funded at Trustees of Indiana University · NIH-11144982 · Data updated 2026-11-12
This project aims to understand how viruses like dengue, West Nile, and Zika make copies of their genetic material, which could help create new treatments and vaccines for people affected by these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Trustees of Indiana University NIH-funded |
| Lab location | 1 site (Bloomington, United States) |
| Project start | March 10, 2011 |
| Project end | June 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $454,201 |
| NIH project number | 5R01AI087856-13 |
| Project ID | NIH-11144982 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who currently have or are at risk for flavivirus infections, such as dengue, West Nile, or Zika, could potentially benefit from future treatments developed from this basic understanding.
✕Less likely to help
Patients with conditions unrelated to flavivirus infections would not directly benefit from this specific research.
What this research studies
Flaviviruses, such as dengue, West Nile, and Zika, cause serious illnesses worldwide, and we currently lack effective treatments or vaccines. This project focuses on understanding the tiny machinery these viruses use to multiply inside cells. By learning exactly how the virus copies its genetic material, we hope to find new ways to stop it. This detailed knowledge is crucial for developing new antiviral medicines and better vaccines to protect people from these infections.
Why it matters
Potential benefit: If successful, this work could lead to the development of new antiviral drugs and more effective vaccines for diseases like dengue, West Nile, and Zika.
How similar studies have gone: While the specific mechanism of NS5 is still being uncovered, similar basic science approaches have successfully informed drug development for other viruses.
Where this research is happening
-
Trustees of Indiana University
Bloomington, United States Active
Researchers
- Principal investigator: Choi, Kyung H — Trustees of Indiana University
- Study coordinator: Choi, Kyung H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.