Understanding how daily rhythms affect cell maturation
How cell maturation is regulated by circadian and metabolic rhythms
This study looks at how our body's natural daily rhythms affect how cells grow and work, using both human and mouse models, to find ways to improve treatments for patients needing better healing and regeneration.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11022211 on NIH RePORTER |
What this research studies
This research investigates how the body's natural daily rhythms, influenced by the 24-hour cycle, affect the maturation of cells. By studying both human and mouse models, the research aims to uncover the mechanisms by which circadian and metabolic rhythms influence how cells become specialized and maintain their functions. The approach includes advanced techniques like single-cell gene expression mapping and gene editing to explore these processes in detail. Patients may benefit from insights that could lead to improved regenerative medicine strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with conditions related to cell maturation or tissue regeneration.
Not a fit: Patients with stable, fully matured tissues or those not affected by cell maturation processes may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in regenerative medicine by enhancing our understanding of how to create fully functional tissues.
How similar studies have performed: Previous studies in chronobiology have shown promising results in understanding cellular functions related to daily rhythms, indicating potential for success in this area.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Alvarez, Juan R — University of Pennsylvania
- Study coordinator: Alvarez, Juan R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.