Understanding how conflicts between DNA replication and transcription affect gene expression
Official title: Characterizing the effect of transcription-replication conflicts on transcription and co-transcriptional processes
Funded at Vanderbilt University · NIH-11135598 · Data updated 2026-11-12
This study looks at how cells handle the tricky situation when they are trying to copy their DNA and make RNA at the same time, which can cause problems that affect how genes work, especially in diseases like cancer, and it hopes to help patients understand how these issues might impact their treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | July 15, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $396,250 |
| NIH project number | 5R35GM155237-02 |
| Project ID | NIH-11135598 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve altered gene expression, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with stable, non-progressive conditions unrelated to gene expression or DNA replication may not benefit from this research.
What this research studies
This research investigates the challenges cells face when both DNA replication and transcription occur simultaneously, which can lead to conflicts that disrupt normal cellular functions. By examining how these conflicts influence the speed and efficiency of RNA polymerase II, the study aims to uncover the effects on gene expression and related processes like alternative splicing. The research will utilize advanced molecular biology techniques to analyze these interactions in various cell types, particularly in the context of diseases such as cancer. Patients may benefit from insights into how these cellular processes contribute to disease progression and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for managing diseases linked to DNA damage and gene expression dysregulation.
How similar studies have gone: While the specific focus on transcription-replication conflicts is relatively novel, related research has shown that understanding gene expression mechanisms can lead to significant advancements in cancer treatment.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Bhowmick, Rahul — Vanderbilt University
- Study coordinator: Bhowmick, Rahul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.