Understanding how chromatin remodeling affects gene expression
Official title: Kinetic Mechanisms of Chromatin Remodeling and Transcription
Funded at Johns Hopkins University · NIH-11065481 · Data updated 2026-11-12
This study is looking at how changes in the structure of DNA affect how genes are turned on and off in living cells, using special imaging tools to see these processes in action, and it could help us understand more about how our genes work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $895,516 |
| NIH project number | 5R35GM149291-03 |
| Project ID | NIH-11065481 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to gene expression dysregulation, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with conditions unrelated to chromatin remodeling or gene expression may not benefit from this research.
What this research studies
This research investigates the mechanisms by which chromatin remodeling influences gene expression in eukaryotic cells. It employs advanced imaging techniques to observe the kinetics of chromatin interactions and transcription processes in real-time, both in living cells and in laboratory settings. By combining these techniques with traditional biochemistry and yeast genetics, the research aims to uncover critical details about how transcription-related proteins function and interact with DNA. The findings could provide insights into the fundamental processes that regulate gene expression.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, which may have implications for treating various diseases.
How similar studies have gone: Other research has shown success in understanding chromatin dynamics and its impact on gene expression, indicating that this approach is built on a foundation of established findings.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Wu, Carl — Johns Hopkins University
- Study coordinator: Wu, Carl
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.