Understanding how certain viruses evade the immune system
Separating the molecular determinants that govern the evolution of Orthoflavivirus NS5-mediated IFN antagonism
This study is looking at how certain viruses that can make people very sick manage to hide from our immune system, focusing on a specific part of the virus, and it hopes to find new ways to help improve treatments for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11162876 on NIH RePORTER |
What this research studies
This research investigates how flaviviruses, which can cause serious diseases, manage to evade the immune response in their hosts. By focusing on a specific viral protein called NS5, the study aims to uncover the different mechanisms these viruses use to suppress the body's natural defenses. The approach involves analyzing the interactions between the virus and host immune factors, which could lead to new insights into viral pathogenesis and potential therapeutic targets. Patients may benefit from a better understanding of how these viruses operate, potentially leading to improved treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals affected by flavivirus infections, such as those with Zika, Dengue, or West Nile virus.
Not a fit: Patients with non-flavivirus related infections or conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective antiviral therapies for diseases caused by flaviviruses.
How similar studies have performed: Previous research has shown success in understanding viral mechanisms of immune evasion, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Bednarski, Eva — Icahn School of Medicine at Mount Sinai
- Study coordinator: Bednarski, Eva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.