Understanding how certain proteins influence gene expression and cell growth
Official title: Mechanisms of recruitment and roles of the BET family chromatin readers in transcription initiation
Funded at Oklahoma Medical Research Foundation · NIH-11019323 · Data updated 2026-11-12
This study is looking at how certain proteins help control gene activity, which is important for how our cells grow and develop, and it aims to understand how these processes might be linked to different human diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | June 10, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $341,000 |
| NIH project number | 1P20GM156711-01 |
| Project ID | NIH-11019323 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to abnormal gene expression, such as certain cancers.
✕Less likely to help
Patients with conditions unrelated to transcriptional regulation or those not affected by gene expression abnormalities may not benefit from this research.
What this research studies
This research investigates the roles of BET family chromatin readers in regulating gene expression, which is crucial for cell growth and differentiation. By studying how these proteins interact with chromatin and transcription factors, the research aims to uncover the mechanisms that control transcriptional programs in various human diseases. The approach includes using model organisms like yeast to explore the conservation of these processes across species, which may provide insights into their functions in human health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases caused by dysregulated gene expression.
How similar studies have gone: Previous research has shown that understanding chromatin dynamics and transcription regulation can lead to significant advancements in treating various diseases, indicating a promising avenue for this investigation.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Donczew, Rafal — Oklahoma Medical Research Foundation
- Study coordinator: Donczew, Rafal
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.