Understanding how certain immune cells affect brain cancer progression
Contribution of Myeloid-Derived Suppressor Cells to Neuro-Inflammatory Alterations and Disease Progression in Glioblastoma
This study is looking at how certain immune cells called myeloid-derived suppressor cells (MDSCs) help glioblastoma, a tough brain tumor, avoid being attacked by the immune system, with the hope of finding new ways to improve treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11112356 on NIH RePORTER |
What this research studies
This research investigates the role of myeloid-derived suppressor cells (MDSCs) in glioblastoma, a highly aggressive brain tumor. By examining how these immune cells contribute to the tumor's ability to evade the immune system, the research aims to uncover new therapeutic targets that could enhance immune responses against the cancer. The study employs a combination of laboratory techniques to analyze the behavior and signaling pathways of MDSCs, with a focus on their impact on cancer stem cells and overall disease progression. Patients may benefit from insights that could lead to more effective treatments for glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioblastoma who are seeking innovative treatment options.
Not a fit: Patients with other types of brain tumors or those not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve survival rates for patients with glioblastoma.
How similar studies have performed: Previous research has shown promise in targeting immune suppression in other cancers, suggesting potential for success in this novel approach for glioblastoma.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Lathia, Justin D. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Lathia, Justin D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.