Understanding how certain genes are regulated during early development
Official title: Regulatory mechanisms governing imprinted domains during early development
Funded at Magee-Women's Res Inst and Foundation · NIH-10865010 · Data updated 2026-11-12
This study is looking at how certain genes are turned on or off depending on whether they come from your mom or dad, especially in very early embryos, to help improve fertility treatments and understand related health issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Magee-Women's Res Inst and Foundation NIH-funded |
| Lab location | 1 site (Pittsburgh, UNITED STATES) |
| Project start | September 15, 2022 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $417,074 |
| NIH project number | 5R01HD109347-03 |
| Project ID | NIH-10865010 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals undergoing assisted reproductive technologies or those with a family history of imprinting disorders.
✕Less likely to help
Patients who are not seeking assisted reproductive options or do not have a history of imprinting disorders may not receive direct benefits from this research.
What this research studies
This research investigates the regulatory mechanisms of genomic imprinting, which controls the expression of specific genes based on their parental origin. By focusing on early development stages, particularly in preimplantation embryos, the study aims to fill knowledge gaps regarding how these imprinting processes are established and maintained. Using innovative techniques like RNA interference screening in mouse stem cells, the researchers are identifying key epigenetic regulators that could influence gene expression. This understanding could have significant implications for assisted reproductive technologies and related imprinting disorders.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes in assisted reproduction and a better understanding of imprinting disorders.
How similar studies have gone: Other research has shown success in understanding genomic imprinting mechanisms, but this specific approach is innovative and aims to uncover novel regulatory pathways.
Where this research is happening
-
Magee-Women's Res Inst and Foundation
Pittsburgh, United States Active
Researchers
- Principal investigator: Mann, Mellissa Rae Wigle — Magee-Women's Res Inst and Foundation
- Study coordinator: Mann, Mellissa Rae Wigle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.