Understanding how certain genes affect alcohol responses
Official title: Control of Alcohol Responses by Actin-Regulating Genes
Funded at University of Utah · NIH-11161321 · Data updated 2026-11-12
This study is looking at how certain genes might affect how people respond to alcohol and develop problems with drinking, using fruit flies to learn more about the science behind it, which could help patients understand their own risks and improve treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $60,832 |
| NIH project number | 3R01AA019526-14S1 |
| Project ID | NIH-11161321 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of alcohol abuse or dependence, particularly those with a family history of alcohol-related disorders.
✕Less likely to help
Patients who do not have any history of alcohol use or dependence may not receive direct benefits from this research.
What this research studies
This research investigates the genetic factors that influence alcohol abuse disorders (AUD) by focusing on specific genes that regulate the actin cytoskeleton. Using a model organism, Drosophila, the study aims to uncover how different genetic regulators affect alcohol response and tolerance in various neural circuits. By analyzing the molecular mechanisms involved, the research seeks to provide insights into the genetic basis of AUD and its implications for treatment. Patients may benefit from a deeper understanding of their genetic predispositions to alcohol-related issues.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for individuals struggling with alcohol dependence.
How similar studies have gone: Previous studies have shown promising results in understanding the genetic factors influencing alcohol responses, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Rothenfluh, Adrian — University of Utah
- Study coordinator: Rothenfluh, Adrian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.