Understanding how certain cells become sperm or egg during early development
Official title: Histone demethylase control of primordial germ cell specification
Funded at University of Wisconsin-Madison · NIH-11140957 · Data updated 2026-11-12
This study is looking at how certain cells in mouse embryos are chosen to become sperm or eggs, focusing on the role of specific proteins in this process, and it aims to help us understand how to support healthy fertility.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $41,423 |
| NIH project number | 5F31HD113347-02 |
| Project ID | NIH-11140957 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals or couples experiencing infertility or developmental issues related to germ cell formation.
✕Less likely to help
Patients who are not affected by fertility issues or do not have a history of developmental disorders may not benefit from this research.
What this research studies
This research investigates the process by which specific cells in mouse embryos are designated to become primordial germ cells (PGCs), which eventually develop into sperm or eggs. The focus is on understanding the role of histone demethylases in the epigenetic changes that occur during this specification process. By using an in vitro model of PGC-like cell differentiation and advanced sequencing techniques, the research aims to uncover how certain genetic regions are protected from early DNA demethylation, which is crucial for proper germ cell development and fertility.
Why it matters
Potential benefit: If successful, this research could lead to new insights into fertility and developmental disorders, potentially improving reproductive health.
How similar studies have gone: Previous research has shown success in understanding epigenetic modifications in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Cormaty, Harshini — University of Wisconsin-Madison
- Study coordinator: Cormaty, Harshini
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.