Understanding how certain cells become sperm or egg during early development
Histone demethylase control of primordial germ cell specification
This study is looking at how certain cells in mouse embryos are chosen to become sperm or eggs, focusing on the role of specific proteins in this process, and it aims to help us understand how to support healthy fertility.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11140957 on NIH RePORTER |
What this research studies
This research investigates the process by which specific cells in mouse embryos are designated to become primordial germ cells (PGCs), which eventually develop into sperm or eggs. The focus is on understanding the role of histone demethylases in the epigenetic changes that occur during this specification process. By using an in vitro model of PGC-like cell differentiation and advanced sequencing techniques, the research aims to uncover how certain genetic regions are protected from early DNA demethylation, which is crucial for proper germ cell development and fertility.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals or couples experiencing infertility or developmental issues related to germ cell formation.
Not a fit: Patients who are not affected by fertility issues or do not have a history of developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into fertility and developmental disorders, potentially improving reproductive health.
How similar studies have performed: Previous research has shown success in understanding epigenetic modifications in other contexts, suggesting that this approach may yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Cormaty, Harshini — University of Wisconsin-Madison
- Study coordinator: Cormaty, Harshini
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.