Understanding how certain brain receptors affect eating behavior
Official title: Examining the role of locus coeruleus glucagon-like peptide-1 receptors in feeding behavior
Funded at University of Pennsylvania · NIH-11035122 · Data updated 2026-11-12
This study is looking at how certain brain receptors affect eating habits and side effects from weight loss treatments, aiming to make these treatments work better and cause less nausea for people trying to lose weight.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | April 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $153,846 |
| NIH project number | 5K01DK133627-03 |
| Project ID | NIH-11035122 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals struggling with obesity who may benefit from improved anti-obesity medications.
✕Less likely to help
Patients who are not overweight or obese may not receive any benefit from this research.
What this research studies
This research investigates the role of glucagon-like peptide-1 (GLP-1) receptors in the brain, specifically in the locus coeruleus, and how they influence feeding behavior and the side effects associated with obesity treatments. By examining these receptors, the study aims to improve the effectiveness of GLP-1 analogs, which are used to suppress appetite and promote weight loss. The research will involve both animal models and potential future human applications to better understand the mechanisms behind food intake suppression and nausea. The ultimate goal is to develop better anti-obesity treatments with fewer side effects.
Why it matters
Potential benefit: If successful, this research could lead to more effective obesity treatments that minimize side effects like nausea.
How similar studies have gone: Previous research has shown promise in targeting GLP-1 receptors for obesity treatment, indicating a potential for success in this approach.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Fortin, Samantha — University of Pennsylvania
- Study coordinator: Fortin, Samantha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.