Understanding how centrosomes are formed during sperm development
Official title: Regulation of Centrosome Biogenesis During Mammalian Spermatogenesis
Funded at Johns Hopkins University · NIH-10889055 · Data updated 2026-11-12
This study looks at how tiny structures in cells, called centrosomes, help make healthy sperm and how mistakes in this process can lead to infertility, with the hope of finding better treatments for couples trying to conceive.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 17, 2023 |
| Project end | October 16, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F31HD111265-02 |
| Project ID | NIH-10889055 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are couples experiencing infertility due to male factors, particularly those with known issues related to sperm cell division.
✕Less likely to help
Patients with infertility not related to sperm development or those with female-factor infertility may not benefit from this research.
What this research studies
This research investigates the role of centrosomes in the process of sperm development, particularly focusing on how errors in meiosis can lead to infertility in couples. By examining the mechanisms of centrosome biogenesis and its impact on chromosome segregation during cell division, the study aims to uncover the cellular processes that contribute to successful sperm formation. The research utilizes biological models to analyze the function of centrioles and associated proteins in spermatocytes, which are crucial for proper cell division and genetic material distribution. Patients may benefit from insights gained that could lead to improved treatments for infertility caused by these cellular errors.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating infertility related to sperm development issues.
How similar studies have gone: Previous research has shown promising results in understanding the role of centrosomes in cell division, indicating that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Skinner, Marnie — Johns Hopkins University
- Study coordinator: Skinner, Marnie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.