Understanding how cells respond to DNA damage using advanced imaging techniques
Mapping the Cellular Responses to DNA Double-Strand Breaks Using On-Demand CRISPR technologies and High-resolution Fluorescence Microscopy
This study is looking at how our cells find and fix serious DNA damage, which can lead to problems like cancer and aging, using advanced technology to see these processes in action, so that we can better understand how to help patients with these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11087658 on NIH RePORTER |
What this research studies
This research investigates how cells detect and repair DNA damage, specifically focusing on double-strand breaks, which are a severe form of DNA damage. By utilizing cutting-edge CRISPR technologies and high-resolution fluorescence microscopy, the study aims to visualize the dynamics of DNA damage response (DDR) factors in real-time within living cells. The goal is to uncover the mechanisms by which these proteins operate and how they contribute to diseases like accelerated aging and cancer. Patients may benefit from insights gained into the cellular processes that underlie their conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing accelerated aging or related genetic conditions that may involve DNA repair deficiencies.
Not a fit: Patients with conditions unrelated to DNA damage or those who do not exhibit accelerated aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for conditions related to DNA damage, such as accelerated aging and certain cancers.
How similar studies have performed: Previous research has shown promise in understanding DNA damage responses, but this specific approach using on-demand CRISPR technologies is relatively novel.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Liu, Yang — University of Utah
- Study coordinator: Liu, Yang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.