Understanding how cells evolve in the body using advanced genomic techniques
Official title: Charting somatic evolution via single-cell multiomics
Funded at Sloan-Kettering Inst Can Research · NIH-10932995 · Data updated 2026-11-12
This study is looking at how cells change and grow in the body, especially in relation to diseases like cancer, to help find better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 5R00HG012579-03 |
| Project ID | NIH-10932995 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with complex diseases, particularly those over 21 years old, who may have undergone significant cellular changes.
✕Less likely to help
Patients with stable, non-evolving conditions or those under 21 years old may not receive direct benefits from this research.
What this research studies
This research focuses on developing innovative single-cell genomics methods to investigate how cells evolve within the human body, particularly in relation to complex diseases like cancer. By utilizing advanced sequencing techniques, the study aims to identify and analyze clonal expansions of cells across different tissues. Patients may benefit from this research as it seeks to uncover the cellular processes that contribute to disease progression, potentially leading to more targeted and effective treatments. The research will be conducted at Stanford University, leveraging its resources and expertise in genomics and computational analysis.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding cancer evolution, improving treatment strategies for patients.
How similar studies have gone: Previous research in single-cell genomics has shown promise in understanding cellular evolution, indicating that this approach could yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Lareau, Caleb Andrew — Sloan-Kettering Inst Can Research
- Study coordinator: Lareau, Caleb Andrew
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.