Understanding how cells communicate through tiny vesicles
Official title: New insights into extracellular signal transduction
Funded at University of Notre Dame · NIH-10899444 · Data updated 2026-11-12
This study is looking at tiny particles that cells release to communicate with each other and their surroundings, which could help us find new ways to diagnose diseases like cancer and infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $328,650 |
| NIH project number | 5R01GM148708-02 |
| Project ID | NIH-10899444 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with conditions that involve cellular signaling disruptions, such as cancer or infectious diseases, may benefit from this research.
✕Less likely to help
Patients with conditions unrelated to cellular signaling or those not requiring diagnostic advancements may not receive direct benefits from this research.
What this research studies
This research investigates how cells send signals to each other and their environment using extracellular vesicles (EVs). These vesicles are small particles released by cells that carry proteins, lipids, and genetic material, playing a crucial role in cell communication. The study aims to explore the diversity of these vesicles and their potential use in diagnostics, particularly in various medical fields such as oncology and infectious diseases. By examining how EVs function and interact, the research seeks to uncover new insights that could enhance our understanding of cellular signaling.
Why it matters
Potential benefit: If successful, this research could lead to innovative diagnostic tools that utilize extracellular vesicles for early detection of diseases.
How similar studies have gone: While the field of extracellular vesicle research is rapidly evolving, many hypotheses regarding their function remain untested, indicating a mix of novel and established approaches.
Where this research is happening
-
University of Notre Dame
Notre Dame, United States Active
Researchers
- Principal investigator: D'souza-Schorey, Crislyn — University of Notre Dame
- Study coordinator: D'souza-Schorey, Crislyn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.