Understanding how cell structures affect gene organization in heart cells
Official title: Deciphering the role of cytoskeletal-nuclear interactions in peripheral chromatin organization
Funded at University of Pennsylvania · NIH-10900502 · Data updated 2026-11-12
This study is looking at how the structures inside heart cells work together and affect gene activity, especially in patients with heart problems caused by issues with a protein called lamin, to find new ways to help improve their health.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HL168922-01A1 |
| Project ID | NIH-10900502 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with laminopathies, particularly those experiencing symptoms of dilated cardiomyopathy.
✕Less likely to help
Patients without genetic mutations related to laminopathies or those not affected by heart conditions may not benefit from this research.
What this research studies
This research investigates the interactions between the cytoskeleton and the nuclear lamina in heart cells, focusing on how these interactions influence the organization of chromatin, which is crucial for gene expression. By studying patients with laminopathies, particularly those who develop dilated cardiomyopathy, the research aims to uncover the mechanisms behind these diseases. The approach includes using advanced techniques like atomic force microscopy to visualize cellular structures and their functions. The ultimate goal is to identify potential therapeutic targets that could improve outcomes for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from dilated cardiomyopathy and other related conditions.
How similar studies have gone: Previous studies have shown promising results in understanding the role of nuclear lamina interactions in heart diseases, suggesting that this research builds on established findings.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Shen, Kaitlyn Marie — University of Pennsylvania
- Study coordinator: Shen, Kaitlyn Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.