Understanding how cadherin molecules assemble in cell junctions
Basis and Function of Lateral Assembly of Cadherin Molecules in Adhesive Junctions of Humans and Model Organisms
This study is looking at how special proteins called cadherins help cells stick together, which is really important for keeping our tissues healthy, and it aims to find out how problems with these proteins might lead to diseases, so we can develop better treatments for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10932142 on NIH RePORTER |
What this research studies
This research investigates the structure and function of cadherin molecules, which are essential for forming adhesive junctions between cells. By using advanced imaging techniques, the study aims to uncover how these molecules interact and assemble into complex structures that are crucial for maintaining tissue integrity. The research will explore both human tissues and model organisms to gain insights into the mechanisms that underlie cell adhesion and the impact of mutations or autoimmune diseases on these processes. Patients may benefit from a better understanding of how these junctions work, potentially leading to new treatments for related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune diseases that affect cell adhesion or those with genetic mutations impacting cadherin function.
Not a fit: Patients with conditions unrelated to cell adhesion or those without autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating autoimmune diseases and other disorders related to cell adhesion.
How similar studies have performed: Previous research has shown promising results in understanding cell adhesion mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Brasch, Julia — University of Utah
- Study coordinator: Brasch, Julia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.