Understanding how brain circuits are formed and function
Official title: Illuminating the Molecular Logic of Mammalian Synaptic Circuit Assembly
Funded at Vanderbilt University · NIH-10909535 · Data updated 2026-11-12
This study is looking at how brain connections are formed and kept strong, which could help us understand conditions like ADHD and autism better, and hopefully lead to new treatments for those who need them.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | September 4, 2024 |
| Project end | September 3, 2027 |
| Funding year | 2024 |
| Award (this year) | $1,349,865 |
| NIH project number | 1DP2MH140134-01 |
| Project ID | NIH-10909535 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals diagnosed with ADHD, autism, or other related behavioral disorders.
✕Less likely to help
Patients with neurological conditions unrelated to synaptic circuit assembly may not receive direct benefits from this research.
What this research studies
This research investigates the molecular mechanisms that govern the assembly and maintenance of synaptic circuits in the mammalian brain. By focusing on cell adhesion molecules and their role in synaptic wiring, the study aims to uncover how these connections are established during brain development and how they may be altered in neurological disorders. Patients may benefit from insights gained into the biological processes underlying conditions like ADHD and autism, potentially leading to new therapeutic strategies. The research employs advanced molecular biology techniques to analyze synaptic connections and their signaling pathways.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurological disorders by enhancing our understanding of synaptic circuit formation.
How similar studies have gone: Other research has shown promise in understanding synaptic mechanisms, but this approach focusing on aGPCRs is relatively novel.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Sando, Richard Cheslock — Vanderbilt University
- Study coordinator: Sando, Richard Cheslock
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.