Understanding how brain cell structures affect neurodevelopmental disorders
Official title: Cytoskeletal pathways of cerebellar dysregulation in neurodevelopmental disorders
Funded at University of Pennsylvania · NIH-10999606 · Data updated 2026-11-12
This study is looking at a protein in the brain that might help explain why some kids have challenges with movement and learning, like those seen in ADHD and autism, by examining specially changed mice to see how this protein affects brain function and behavior.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 23, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $830,168 |
| NIH project number | 1R01MH136674-01A1 |
| Project ID | NIH-10999606 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children diagnosed with ADHD, autism spectrum disorder, or related neurodevelopmental conditions.
✕Less likely to help
Patients with neurodevelopmental disorders not linked to βII-spectrin deficiencies may not benefit from this research.
What this research studies
This research investigates the role of a protein called βII-spectrin in the brain, particularly in the cerebellum, which is crucial for motor control and cognitive functions. By studying mice with specific genetic changes, the research aims to uncover how deficiencies in βII-spectrin lead to symptoms associated with conditions like ADHD and autism. The team will use advanced techniques, including microscopy and electrophysiology, to explore the cellular mechanisms involved and how they affect brain function and behavior. The findings could provide insights into the underlying causes of various neurodevelopmental disorders.
Why it matters
Potential benefit: If successful, this research could lead to new understanding and potential treatments for neurodevelopmental disorders such as ADHD and autism.
How similar studies have gone: Previous research has shown promising results in understanding the role of cytoskeletal proteins in neurodevelopmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Lorenzo, Damaris N — University of Pennsylvania
- Study coordinator: Lorenzo, Damaris N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.