Understanding how blood stem cells interact with their environment
Official title: Reprogramming of hematopoietic stem cells during contact with the perivascular niche
Funded at University of Wisconsin-Madison · NIH-10943341 · Data updated 2026-11-12
This study is looking at how special blood-making cells interact with their surrounding environment to grow and move in the body, using zebrafish and mice to help understand this process better, which could eventually lead to better treatments for blood diseases and cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $493,810 |
| NIH project number | 1R01HL174965-01 |
| Project ID | NIH-10943341 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with blood diseases or cancers who may benefit from hematopoietic stem cell transplantation.
✕Less likely to help
Patients with conditions unrelated to blood diseases or those who are not candidates for stem cell transplantation may not benefit from this research.
What this research studies
This research investigates the interactions between hematopoietic stem and progenitor cells (HSPCs) and the niche cells that surround them, which are crucial for regulating their function. By using zebrafish and mice as model organisms, the study aims to uncover how these cells migrate and mature through different tissues during development. The researchers will explore the role of specific growth factors, such as vascular endothelial growth factor c (vegfc), in the release and fate determination of HSPCs. This knowledge could lead to improved transplantation techniques for treating blood diseases and cancers.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of stem cell transplants, leading to better outcomes for patients with blood disorders.
How similar studies have gone: Previous research has shown promising results in understanding stem cell behavior and interactions in similar models, indicating potential for success in this area.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Tamplin, Owen James — University of Wisconsin-Madison
- Study coordinator: Tamplin, Owen James
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.