Understanding how blood stem cells divide and develop
Official title: Defining the molecular basis controlling hematopoietic stem cell symmetric and asymmetric divisions
Funded at Research Inst of Fox Chase Can Ctr · NIH-11144633 · Data updated 2026-11-12
This study is looking at how blood stem cells decide whether to make more stem cells or turn into different types of blood cells, which could help find new treatments for blood-related diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst of Fox Chase Can Ctr NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $249,000 |
| NIH project number | 4R00DK128602-03 |
| Project ID | NIH-11144633 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with hematologic diseases or conditions affecting blood cell production.
✕Less likely to help
Patients with non-hematologic conditions or those not affected by blood diseases may not benefit from this research.
What this research studies
This research investigates the mechanisms that control how hematopoietic stem cells (HSCs) divide and differentiate into various blood cells. By using advanced techniques like FATE-seq, the study aims to identify the molecular programs that dictate whether these stem cells self-renew or commit to becoming specialized blood cells. The research focuses on the role of specific RNA modifications and proteins in regulating these division choices, which are crucial for maintaining healthy blood cell levels. Patients may benefit from insights gained that could lead to new treatments for blood-related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for hematologic diseases by improving our understanding of blood stem cell behavior.
How similar studies have gone: Other research has shown promising results in understanding stem cell behavior, making this approach both relevant and potentially impactful.
Where this research is happening
-
Research Inst of Fox Chase Can Ctr
Philadelphia, United States Active
Researchers
- Principal investigator: Luo, Hanzhi — Research Inst of Fox Chase Can Ctr
- Study coordinator: Luo, Hanzhi
Related research
Other NIH-funded projects on the same topics.
-
Omega-3 dietary supplement profiles for Asian American adults at risk for cardiometabolic diseases
A grant to better understand how omega-3 supplements affect heart and metabolic health in Chinese, Vietnamese, and Filipino adults ages 18–64.
-
Targeting the IL-1R Pathway to Boost Immunotherapy for Anaplastic Large Cell Lymphoma
Aims to make CD30 CAR therapies work better for people with ALCL by blocking a immune-evasion pathway.
-
How an immune signal in brain support cells helps breast cancer spread to the brain
This project looks at whether a specific immune signal in brain support cells (astrocytes) helps breast cancer cells grow in the brain, aiming to help people with breast cancer that has spread to the brain.
-
Intercepting pancreatic cancer by targeting a tumor-supporting network
A patient-facing overview of a funded project that aims to stop pancreatic cancer from progressing by targeting the supportive tissue around tumors.
-
Refolding Mutant p53: A Strategy to Help People with Li-Fraumeni Syndrome
Aims to develop drugs that stabilize mutant p53 in people with Li-Fraumeni syndrome to prevent cancers before they develop.
-
Informatics Core supports precision cancer research at Fox Chase Cancer Center
A data and stats support program helps cancer researchers design smarter studies and manage high-quality data to speed preventive and early-interception cancer work.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.