NIH-funded research U01 cooperative agreement

Population modeling to reduce bladder cancer burden

Official title: Population modeling for bladder cancer prevention and control

Funded at Brown University · NIH-11495895 · Data updated 2026-11-12

Aimed at predicting and guiding effective, population-based ways to prevent and control bladder cancer.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionBrown University
NIH-funded
Lab location1 site (Providence, United States)
Project startSeptember 18, 2026
Project endAugust 31, 2031
Funding year2026
Award (this year)$1,231,387
NIH project number1U01CA319218-01
Project IDNIH-11495895 on NIH RePORTER

Who could benefit from this research

Could help

Not applicable to a single patient group; findings will inform prevention and management for adults at risk or living with bladder cancer.

Less likely to help

Early-stage findings may not translate immediately into individual patient care.

What this research studies

This project uses population modeling to understand how prevention, screening, and treatments could reduce bladder cancer cases and deaths. It builds on recent biomarker and treatment advances to forecast impact at the population level and to optimize resource use. The work will inform decisions about policies, screening strategies, and treatment pathways that affect people at risk or living with bladder cancer. The focus is on translating complex data into actionable insights that could help patients receive better care.

Why it matters

Potential benefit: If successful, it could lead to more effective prevention and treatment strategies that reduce bladder cancer cases and improve patient outcomes.

How similar studies have gone: Previous population modeling efforts have shown potential to influence cancer prevention and care decisions, but disease-specific models for bladder cancer are evolving.

Where this research is happening

  • Brown University
    Providence, United States
    Active

Researchers

  • Principal investigator: Trikalinos, Thomas — Brown University
  • Study coordinator: Trikalinos, Thomas

Related research

Other NIH-funded projects on the same topics.

  • Blocking a new immune checkpoint in bladder cancer

    Researchers are trying medicines that block a newly found immune pathway to help people with bladder cancer, especially those whose tumors do not respond to current immunotherapy.

    NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11473209

  • Nrf2 in T cells and how it could boost immune power against bladder cancer

    A small grant will explore how a T-cell protein called Nrf2 affects muscle-invasive bladder cancer and whether targeting it could help patients respond better to immune therapies.

    NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11441846

  • Understanding why bladder cancer spreads and resists treatment

    This grant studies how advanced bladder cancer changes and spreads across the body, aiming to uncover why it’s hard to treat.

    NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11435060

  • Molecular clues to bladder cancer cell changes and therapy response

    This NIH grant looks at how bladder cancer cells change their identity and how that affects response to treatment, with a focus on aggressive neuroendocrine variants.

    NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-11425761

  • Repurposing spironolactone to treat bladder cancer inside the bladder

    Aims to repurpose spironolactone as an intravesical treatment for non-muscle invasive bladder cancer to help prevent recurrence and progression.

    NIH research Roswell Park Cancer Institute Corp · Buffalo, United States · NIH-11420769

  • Racial and social factors linked to bladder cancer outcomes

    This grant builds a partnership between Baylor College of Medicine and Texas Southern University to understand how people’s social and living conditions affect bladder cancer outcomes and treatment results.

    NIH research Baylor College of Medicine · Houston, United States · NIH-11417547

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.