Understanding how BCL10 and MALT1 proteins affect immune cell function
Official title: BCL10-MALT1 protein-protein interaction in lymphocyte function and dysfunction
Funded at University of Pittsburgh at Pittsburgh · NIH-11109582 · Data updated 2026-11-12
This study is looking at how two proteins, BCL10 and MALT1, work together in immune cells to help us understand and find better treatments for conditions like psoriasis and colitis.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | June 12, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $171,373 |
| NIH project number | 5K08AI177744-03 |
| Project ID | NIH-11109582 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from autoimmune disorders, particularly psoriasis and colitis.
✕Less likely to help
Patients with non-autoimmune conditions or those not affected by inflammatory diseases may not benefit from this research.
What this research studies
This research focuses on the interaction between two important proteins, BCL10 and MALT1, which play a crucial role in the functioning of immune cells called lymphocytes. By studying how these proteins interact, the research aims to uncover the underlying mechanisms that lead to immune disorders such as psoriasis and colitis. The approach includes advanced laboratory techniques to manipulate these protein interactions and assess their effects on inflammation and immune responses. This work could lead to new therapeutic strategies for treating inflammatory diseases.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autoimmune conditions like psoriasis and colitis.
How similar studies have gone: Previous research has shown promising results in targeting protein interactions for therapeutic benefits in similar inflammatory conditions.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Maurer, Lisa M — University of Pittsburgh at Pittsburgh
- Study coordinator: Maurer, Lisa M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.