Understanding how assisted reproduction technologies may cause genetic errors in embryos
Official title: Identifying Molecular Signatures of Genomic Imprinting Errors
Funded at Magee-Women's Res Inst and Foundation · NIH-11059203 · Data updated 2026-11-12
This study is looking into how assisted reproductive technologies might affect the DNA of embryos, which could lead to genetic issues in babies, and it aims to find ways to improve these technologies for better health outcomes in future pregnancies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Magee-Women's Res Inst and Foundation NIH-funded |
| Lab location | 1 site (Pittsburgh, UNITED STATES) |
| Project start | April 1, 2022 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $395,989 |
| NIH project number | 5R01HD101574-04 |
| Project ID | NIH-11059203 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include couples undergoing assisted reproductive technologies who are concerned about potential genetic risks to their embryos.
✕Less likely to help
Patients who are not using assisted reproductive technologies or those who have no interest in conceiving through ART may not benefit from this research.
What this research studies
This research investigates the potential genetic errors that can occur in embryos conceived through assisted reproductive technologies (ART). It focuses on how these technologies might disrupt the normal processes of DNA methylation, which is crucial for proper embryo development. By studying the molecular signatures associated with these errors, the research aims to identify specific factors that contribute to increased risks of genetic disorders in children born via ART. Patients may benefit from insights that could lead to improved ART practices and better outcomes for future pregnancies.
Why it matters
Potential benefit: If successful, this research could lead to safer assisted reproductive technologies and healthier pregnancies for couples facing infertility.
How similar studies have gone: Previous studies have indicated that ART can lead to increased genetic risks, suggesting that this research builds on established findings rather than exploring entirely untested territory.
Where this research is happening
-
Magee-Women's Res Inst and Foundation
Pittsburgh, United States Active
Researchers
- Principal investigator: Mann, Mellissa Rae Wigle — Magee-Women's Res Inst and Foundation
- Study coordinator: Mann, Mellissa Rae Wigle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.