Understanding how anger and hostility affect depression
Official title: Neural and Behavioral Mechanisms of Angry Hostility in Depression
Funded at Ohio State University · NIH-11082501 · Data updated 2026-11-12
This study is looking at how feelings of anger and hostility can affect depression in adults, and it hopes to find ways to improve treatments by understanding how our brains react when we feel upset.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $641,592 |
| NIH project number | 5R01MH131606-03 |
| Project ID | NIH-11082501 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 who experience significant anger and hostility as part of their depressive symptoms.
✕Less likely to help
Patients who do not experience anger or hostility as part of their depression may not benefit from this research.
What this research studies
This research investigates the connection between anger, hostility, and depression in adults. It aims to identify specific brain functions and behaviors associated with a tendency to react aggressively after negative experiences. By studying these patterns, the research seeks to develop better treatment strategies that target the underlying neurobiological mechanisms of depression. Patients may undergo assessments to evaluate their emotional responses and brain activity related to anger and hostility.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for depression that specifically address anger and hostility, improving overall patient outcomes.
How similar studies have gone: Previous research has shown promising results in understanding the links between emotional responses and depression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Fournier, Jay C — Ohio State University
- Study coordinator: Fournier, Jay C
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.