Understanding how alcohol tolerance affects drinking behavior
Alcohol Tolerance as a Driver of Self-Administration
This study looks at how our bodies get used to alcohol and how our first experiences with it can affect that process, using fruit flies to explore the genes involved, which could help us find better ways to support people dealing with alcohol use issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10953314 on NIH RePORTER |
What this research studies
This research investigates the relationship between alcohol tolerance and self-administration of alcohol, particularly focusing on how initial reactions to alcohol influence tolerance development. Using Drosophila as a model organism, the study aims to analyze genetic factors that contribute to alcohol sensitivity and tolerance. By examining over 120 genetic manipulations, researchers hope to uncover mechanisms that drive alcohol use disorder and its progression. The findings could lead to better understanding and potential interventions for individuals struggling with alcohol use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use or those at risk of developing alcohol use disorder.
Not a fit: Patients who do not consume alcohol or have no history of alcohol use disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into the biological mechanisms of alcohol use disorder, leading to improved prevention and treatment strategies for patients.
How similar studies have performed: Previous research has shown success in using genetic models to study alcohol-related behaviors, indicating that this approach has potential for yielding valuable insights.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Rothenfluh, Adrian — University of Utah
- Study coordinator: Rothenfluh, Adrian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.