Understanding how airway inflammation affects fear and anxiety
Official title: Airway inflammation and fear: elucidating immune mediators and neural substrates
Funded at University of Cincinnati · NIH-10979197 · Data updated 2026-11-12
This study is looking at how inflammation from severe asthma might affect fear and anxiety in people with PTSD, using mice to understand the connection better, which could lead to new treatments for those dealing with both conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | September 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $463,425 |
| NIH project number | 1R01MH133070-01A1 |
| Project ID | NIH-10979197 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of severe asthma and symptoms of PTSD.
✕Less likely to help
Patients without asthma or those who do not experience PTSD symptoms may not benefit from this research.
What this research studies
This research investigates the relationship between airway inflammation, particularly from severe asthma, and fear regulation in individuals with posttraumatic stress disorder (PTSD). By using mouse models, the study aims to uncover the immune and neural mechanisms that link asthma-related factors to fear dysregulation. The researchers will explore how specific immune signals, like IL-17A, affect brain regions involved in fear processing, potentially leading to new therapeutic approaches for those suffering from PTSD and asthma. The findings could help identify individuals at risk for PTSD based on their immune responses.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve mental health outcomes for patients with PTSD, especially those with asthma.
How similar studies have gone: Previous research has shown promising results in understanding the links between immune responses and mental health, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Sah, Renu — University of Cincinnati
- Study coordinator: Sah, Renu
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.