Understanding how aging changes FSH signals affect the FSH receptor
Official title: Project 3: Understanding the Role of FSHR Oligomerization and Trafficking in Transducing Age-dependent Changes in FSH Glycoforms
Funded at Wichita State University · NIH-11401796 · Data updated 2026-11-12
This research looks at how aging alters FSH hormones and how their different forms interact with the FSH receptor in the ovary to influence cellular signaling.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wichita State University NIH-funded |
| Lab location | 1 site (Wichita, United States) |
| Project start | April 15, 2009 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $246,223 |
| NIH project number | 5P01AG029531-14 |
| Project ID | NIH-11401796 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals undergoing assisted reproduction or fertility treatment where aging-related FSH changes may be relevant.
✕Less likely to help
People not involved in fertility treatments or those without aging-related hormonal changes may see limited direct benefit.
What this research studies
As a patient, you may hear that aging affects fertility through hormones. This project studies how age-related changes in FSH glycoforms influence receptor behavior, including how receptors pair up and move inside cells. The researchers will examine human granulosa cells to see how these changes affect the signaling that controls follicle development. By understanding this process, the work could point to new ways to support fertility in older individuals.
Why it matters
Potential benefit: If successful, the work could lead to better fertility treatments tailored to age-related hormonal changes.
How similar studies have gone: Previous work indicates aging alters FSH glycoforms and receptor signaling, with some evidence of differential effects by glycoform.
Where this research is happening
-
Wichita State University
Wichita, United States Active
Researchers
- Principal investigator: Jonas, Kim Carol — Wichita State University
- Study coordinator: Jonas, Kim Carol
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.