Role of FSH glycoforms in ovarian aging and granulosa cell function
Official title: Project 2: Role of Glycosylation in FSH Signaling in FSH Target Cells
Funded at Wichita State University · NIH-11401786 · Data updated 2026-11-12
A study in ovarian cells and aging mice will explore how different forms of FSH influence cell signals and genes involved in aging and fertility.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wichita State University NIH-funded |
| Lab location | 1 site (Wichita, United States) |
| Project start | April 15, 2009 |
| Project end | May 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $356,360 |
| NIH project number | 5P01AG029531-14 |
| Project ID | NIH-11401786 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are women approaching or experiencing age-related fertility changes and researchers with access to human or human-like ovarian cell models.
✕Less likely to help
People without ovarian aging issues or those not involved in reproductive biology may not directly benefit.
What this research studies
This project looks at how aging affects ovarian cells and how different sugar-bearing forms of FSH change the activity of important transcription factors in granulosa cells. Researchers will use aging mouse models and lab cell systems to study how FSH glycoforms modulate CREB and YAP1 signaling, affecting cell growth, death, and aging processes. The goal is to connect FSH glycoform biology to the decline in fertility seen with age and to uncover potential targets for preserving ovarian function. Participation would involve laboratory work with animal models and human-relevant cell cultures, not direct patient care.
Why it matters
Potential benefit: If successful, this work could identify new targets to preserve or improve fertility in aging individuals.
How similar studies have gone: Previous work shows glycoforms of FSH differ in activity and signaling, supporting exploration of transcription factor pathways; this project builds on those findings with aging models.
Where this research is happening
-
Wichita State University
Wichita, United States Active
Researchers
- Principal investigator: Davis, John S — Wichita State University
- Study coordinator: Davis, John S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.