Understanding how aging and injury affect muscle function.
Official title: Age, Injury, and the Neuromuscular Junction
Funded at University of Minnesota · NIH-10890161 · Data updated 2026-11-12
This study looks at how aging and muscle injuries affect the connections between nerves and muscles, with the goal of finding ways to help older adults and those who have lost muscle strength move better and recover more effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | August 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $149,904 |
| NIH project number | 5K02AG081488-02 |
| Project ID | NIH-10890161 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above, particularly those experiencing muscle weakness or loss.
✕Less likely to help
Patients under 65 years of age or those without neuromuscular issues may not benefit from this research.
What this research studies
This research investigates the changes that occur at the neuromuscular junction (NMJ) as people age and after muscle injuries. It aims to identify the mechanisms that lead to neuromuscular dysfunction, which can significantly impact physical movement and daily activities. By studying the NMJ, the research seeks to find ways to improve muscle function and recovery in older adults and those who have experienced muscle loss. The approach includes evaluating the NMJ's stability and function in both aging individuals and those with volumetric muscle loss.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for muscle dysfunction in older adults, enhancing their mobility and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding neuromuscular junction changes with aging, indicating that this approach has potential for significant advancements.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Greising, Sarah M — University of Minnesota
- Study coordinator: Greising, Sarah M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.