Understanding how aging affects the immune system through NLRX1
Official title: Investigating the interface of NLRX1 and immune aging
Funded at Yale University · NIH-10801956 · Data updated 2026-11-12
This study is looking at a protein called NLRX1 to see how it affects the immune system as we get older, especially how it might help memory T cells grow and keep our immune system strong, which could lead to better health for older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $351,750 |
| NIH project number | 1R01AG082433-01A1 |
| Project ID | NIH-10801956 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related immune decline.
✕Less likely to help
Patients who are younger and do not exhibit signs of immune aging may not benefit from this research.
What this research studies
This research investigates the role of NLRX1, a protein found in mitochondria, in the aging immune system. It focuses on how changes in NLRX1 levels may contribute to the expansion of memory T cells and the overall decline in immune function as people age. By studying both human blood samples and mouse models, the research aims to uncover the mechanisms behind immune aging and its implications for health in older adults. The findings could lead to new strategies for enhancing immune responses in the elderly.
Why it matters
Potential benefit: If successful, this research could lead to improved immune health and reduced risk of infections and cancers in older adults.
How similar studies have gone: Previous research has shown promising results in understanding immune aging, but this specific investigation into NLRX1 is relatively novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Kang, Insoo — Yale University
- Study coordinator: Kang, Insoo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.